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Medicinal Sciences Researches

Development of Nano-biomaterials Through Rational Hybridization of Biomolecule and Artificial Molecule

Masato Ikeda : PhD
Research Area:Nano-Biomaterials/Supramolecular Science/Molecular Machinery/Artificial Cell/Peptide Science/Nucleic Acid Science/

Our research subject is to develop nano-biomaterials through rational hybridization of biomolecule and artificial molecule. Through elaborate design and synthesis at molecular level, we are aiming to develop nano-biomaterials (including hydrogel, nanosensor, and drug carrier) capable of sensing and responding their surrounding environments.

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Research for Development of New Protein Drugs by Preparing Proteins Including a Non-natural Amino Acid in a Site-specific Manner

Takashi Yokogawa : PhD
Research Area:Protein Engineering

We thoroughly investigate the difference of protein synthesis system among three domains of life and try to combine the virtue of each domain to create a highly-productive hybrid protein synthesis system. By using the hybrid system, we introduce a non-natural amino acid into a protein in a site-specific manner and apply the high-value added protein to the development of protein drugs or tools for drug discovery.

The overall structure of the yeast tyrosyl-tRNA synthetase complexed with its cognate tyrosine tRNA.

Synthesis of Brain-penetrating Molecular Probes Targeting Intractable Central Nervous System Disease

Hiroko Koyama : PhD
Reserach Area : Organic Chemistry / Medicinal Chemistry / Radionuclear Labeling Chemistry

Our research subject is to develop a novel PET probes toward drug development and diagnosis of brain functional disorder such as Alzheimer's disease. Our research is syntheses of PET probes for drug candidates by our original rapid 11C- and 18F-labeling methods, and evaluate of their blood-brain barrier permeability and brain dynamics (particularly target specificity). This research is conducted in an interdisciplinary research field in which chemistry, engineering, biology, pharmacy, and medicine are closely collaborate, and our research group is mainly in charge of the molecular design, synthesis, and labeling chemistry.

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Synthesis of the 11C-labeld PET tracer of tau aggregation
inhibitor and images in normal rat brains.
Bioorg. Med. Chem. Lett. 29 (2019) 2107-2111).

Development of Novel Ras-targeting Anticancer Drug

Rho Honda: PhD
Research Area:Structural Biology / Protein Science

Mutations in the RAS gene family are found in approximately 30% of all cancers, yet to date no drugs that selectively inhibit mutant Ras have been brought to market. This is due to the fact that binding pockets for low-molecular-weight compounds are absent on the molecular surface of mutant Ras, making conventional low-molecular-weight drug discovery methods useless for developing drugs that can bind to mutant Ras selectively and with high affinity. We are currently developing a method that differs from the conventional approach. In this new method, high-molecular weight proteins are introduced into the cell to inhibit mutant Ras.

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Rational Drug Discovery Based on Biophysical Approach

Yuji O Kamatari: PhD
Research Area : Rational drug discovery, Biophysics, Structual biology, Protein science

Our research theme is rational drug discovery based on biophysical approach. We design new drugs based on the target protein structure, and use various biophysical methods (DSF, ITC, NMR etc.) for drug screening, understanding the mechanism of action, and feeding back to the drug design. Our research targets a wide range of modalities from low molecular weight compounds to antibodies.

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Molecular Mechanisms of Cancer Invasion and Metastasis

Hiroshi Ueda :PhD
Research Area : Biochemistry / Cell Biology

Our research focuses on the molecular mechanisms of cancer invasion and metastasis. Through functional analysis of human genes, we aim to gain an understanding of how cellular morphology and motility are regulated during infiltration and metastasis of cancer cells.

Staining of cells with and without transfer of a gene involved in morphological regulation

Understanding Life Activities through the Development of Cutting-edge Measurement Technologies

Yukihiro Esaka: PhD
Research Area:Precision Separation and Analytic Chemistry for Biomolecules

Our research topic is the development and application of advanced separation and analysis methodology to facilitate a better understanding of life activities.

We are developing novel separation and high-sensitivity detection methods for capillary electrophoresis (CE) and liquid chromatography systems that are indispensable in the analysis of biomolecule functions. We are also investigating DNA damage processes by combining these systems with mass spectroscopy (MS).

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CE-MS interface

Drug Discovery Based on Monitoring of Cellular Energy Metabolism

Hiroshi Takemori : PhD
Research Area:Pathological Chemistry

We are developing methods to screen drugs by monitoring cellular energy metabolism, which could be an indicator of intracellular signal transduction and cell toxicity.

 Diseases cause metabolic shifts of cellular energy.

Elucidation of cellular control mechanisms triggered by endoplasmic reticulum/Golgi stress responses

Kentaro Oh-hashi :PhD
Research Area:Molecular Biology / Neuroscience

The research theme is molecular and biological analysis of signaling mechanisms triggered by homeostasis of endoplasmic reticulum and Golgi apparatus, and its abnormalities. More precisely, to deepen our understanding of the various diseases involving endoplasmic reticulum/Golgi abnormalities (e.g., neurodegenerative diseases), we are working to elucidate new stress response systems by searching for new stress response factors using microarrays and by establishing and analyzing cell strains deficient in the factors identified.

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Synthesis and Evaluation of Disulfide Compounds with Modified Orbital Energy

Takuhei Yamamoto :PhD
Research Area:Organic Chemistry/ Electrochemistry

Our research program is focused on the synthesis and characterization of disulfide compounds that the molecular orbital energy is modified by neighboring groups to gain insight into how cystinyl proteins function in biological systems.

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MicroRNA Medicine for Cancer Diagnostics and Therapy

Yukihiro Akao : MD
Research Area : Medical Oncology

Our work is centered on microRNA medicine encompassing both laboratory discoveries and clinical applications. MicroRNA plays an important role in the expression of oncogenes and tumor suppressor genes, and abnormal microRNA expression is closely associated with oncogenesis. By elucidating these mechanisms, we aim to contribute to cancer diagnostics and therapeutics. The biological significance of membrane vesicles released by cancer cells is another focus of our research.

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Cancer cells release exosomes containing microRNA, mRNA, and proteins that are essential for their survival.

Endowed Chair : Kotosugi

Yukihiro Akao :MD , Research Area:Medical Oncology

We investigate biological activities of secondary metabolites contained in Kotosugi(Taxus), with in the aim of applying the results in complementary medicine and cancer prevention. The mechanisms underlying the anti-cancer properties of these metabolites and the involvement of microRNAs are of particular interest.

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Department of Multi-stage Polymerized Fermentation

Hiroshi Ueda, PhD Research Area:Biochemistry / Cell Biology
Kohei Morikawa, PhD Research Area:Food Health Science / Natural Products Chemistry /Food Biochemistry / Complementary Medicine

Our research is about the effects of plant fermented foods produced by multi-stage polymerized fermentation on lifestyle-related diseases and cancer prevention. Especially, regarding the effect of cell aging inhibitory effects, the mechanism and miRNA, the involvement of physiologically active ingredients will also be examined. In addition, the results will be linked to the prevention of lifestyle-related diseases and cancer.

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The characteristic production of plant fermented food materail by multi-stage polymerized fermentation.

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